If you’ve been prescribed weight loss medication or a GLP-1 injection like
Ozempic®
or
Wegovy®
for chronic weight management or Type 2 diabetes, you may be wondering what to expect. You may also have questions about how it could affect your diet, lifestyle, and overall quality of life.

In the following guide, we cover what you need to know to prepare for your first 90 days on semaglutide weight loss medication. We also recommend speaking with your healthcare provider to fully understand the potential risks, effects, and benefits.

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Weight Loss Medication Timeline

There are several prescription options for weight loss, ranging from injectable GLP-1 medications like Wegovy® or Ozempic® (in some cases) to oral pills such as Contrave® or Xenical®. Finding the right one often depends on your health history, lifestyle, and personal preferences. Working closely with your healthcare provider can help you select a medication that is safe for you and fits your lifestyle, giving you the best chance for long-lasting results.

Month 1: Getting Started

The first 30 days on weight loss medication are the adjustment period.
Each individual’s experience this month will vary, but on average, here’s what you can expect:

Lower dosage: Your healthcare provider will start you on a low dose and gradually build up as needed to minimize side effects.
Appetite changes: You may notice slight appetite changes, such as feeling fuller after smaller meals or having less of an appetite.
Potential side effects: You might experience mild nausea, vomiting, diarrhea, constipation, and fatigue or light-headedness after meals.
Note: Keep a journal and write down any potential side effects, changes in appetite, mood, sleep, etc., to share with your healthcare provider.

Month 2: Momentum Builds with More Noticeable Results

Dosage increases: With your healthcare provider’s guidance, the dosage may be increased.
Weight loss: Noticeable weight loss may occur. In a
study on semaglutide treatment,
average body-weight loss was 5.9% at 3 months^[1].
Craving control: Many people report a noticeable reduction in food cravings and a greater sense of control over portion sizes.

Note: To protect your muscle while losing weight, strength training is essential and it’s best to start right away. Even a simple routine with bodyweight exercises, resistance bands, or light weights will make a difference. Walking or other light movement is great for overall health, but it’s strength training that helps you keep muscle as the pounds come off.

Month 3: Continued Progress

More weight loss: Weight loss continues steadily for most people during this time.
Healthier eating habits: This stage is typically where healthier eating habits start to solidify. You may feel full with smaller portions without intentional restriction, and become more aware of your portion sizes.
Side effects: The initial side effects tend to fade during this time, although some gastrointestinal effects may persist for some individuals.

Weight Loss Medication: Essential Takeaways

Remember individual responses vary: Everyone reacts differently to weight loss medication, and results can vary based on factors like starting weight, genetics, diet, and exercise habits.

Check in with your healthcare provider regularly: Regular appointments help monitor progress and manage any side effects.

Understand that serious side effects can occur: Though uncommon, some people may experience serious issues such as pancreatitis, gallbladder problems, gastroparesis, or bowel obstruction. Seek immediate medical attention if you experience severe abdominal pain, persistent vomiting or diarrhea, or other concerning symptoms.

Know that lifestyle choices matter: Weight loss medication works best when paired with a healthy diet and regular exercise.

Ready to Take the Next Step in Your Weight Loss Journey?

Connect with a Rocky Health practitioner today via a quick assessment to discuss whether semaglutide or another weight loss medication is right for you. Our team can guide you through your options, answer your questions, and help create a plan that fits your lifestyle and health goals.

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Resources

Ghusn, Wissam, et al.

“Weight Loss Outcomes Associated with Semaglutide Treatment for Patients with Overweight or Obesity.”

JAMA Network Open, vol. 5, no. 9, 2022, article e2231982.

Disclaimer: This article is intended for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider with any questions about a medical condition or treatment.

Editorial Standards: At Rocky Health, we’ve made it our mission to support men and women with trustworthy, easy-to-understand medical and health information online.
Read more about our editorial standards here.

Weight Loss

Your First 90 Days on Weight Loss Medication: What to Expect

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